Ldh High In Pregnancy

Ldh High In Pregnancy – The diagnosis of hypertension in pregnancy as defined by the Task Force (2000) is shown in Figure 23-1. in the table. There are five types of hypertension that interfere with pregnancy: (1) preeclampsia (early hypertension caused by pregnancy), (2) preeclampsia, (3) eclampsia, (4) preeclampsia leading to severe disease. , and (5) severe illness. The most important point in this group is to distinguish hypertension, which begins in pregnancy, from preeclampsia, which is a more serious disease.

And 140/90 mm Hg or greater using Korotkoff phase V to determine diastolic pressure. Edema is abandoned as a diagnostic tool because it occurs in so many pregnant women that it can be discriminatory. In the past, a systolic blood pressure of 30 mm Hg or a diastolic blood pressure of 15 mm Hg was recommended as the diagnostic criteria, although the actual values ​​were less than 140/90 mm Hg. This is no longer accepted because evidence shows that women in this group will not suffer the effects of pregnancy. This means that women with systolic blood pressure above 30 mmHg or diastolic blood pressure above 15 mmHg should be closely monitored.

Ldh High In Pregnancy

Ldh High In Pregnancy

Hypertension is common during pregnancy and accounts for one-third of all deaths, along with bleeding and infection, causing many women to become ill and die from pregnancy. How pregnancy can be caused or worsened High blood pressure has not been resolved despite years of research, and hypertension is one of the most unsolved problems in gynecology.

Pdf] Lactate Dehydrogenase As A Biochemical Marker Of Adverse Pregnancy And Fetal Outcome In Preeclampsia: A Comparative Study

As can be seen in Figure 23-1. Table, gestational hypertension is diagnosed in women whose blood pressure reaches 140/90 mm Hg or higher for the first time during pregnancy, but who are still pregnant.

If preeclampsia does not develop and blood pressure returns to normal by 12 weeks post-delivery. In particular, women with high blood pressure may have other symptoms associated with preeclampsia, such as headache, epigastric pain, or thrombocytopenia, which affect management.

Preeclampsia is a pregnancy-related disease that results in vasospasm and endothelial activation resulting in reduced organ production. Proteinuria is defined as 300 mg or more protein in the urine in 24 hours or more than 30 mg/dL (1 + dipstick) in a random urine sample. The amount of proteinuria can fluctuate significantly over a 24-hour period, even in severe cases. Therefore, a random sample may not show significant proteinuria. Combination of proteinuria

The risk of preeclampsia is reported to be around 5%, although dramatic variations have been reported. The incidence is proportional, and infertile women have a higher risk (7 to 10 percent) than fertile women. Other risk factors associated with preeclampsia include multiple pregnancies, a history of high blood pressure, maternal age over 35 years, maternal obesity, and African-American ethnicity.

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The severity of preeclampsia is assessed by its prevalence and 23-2. The number of anomalies listed in the table. The higher the density, the more abortions are needed.

In particular, the distinction between mild and severe preeclampsia can be misleading, as mild symptoms can quickly progress to severe disease.

Eclampsia is the occurrence of seizures in a woman with preeclampsia that cannot be caused by other causes. Constipation can be very dangerous and can happen before, during or after childbirth. Eclampsia can occur 10 days after birth.

Ldh High In Pregnancy

, regardless of the cause, leads to the development of superficial preeclampsia or eclampsia. This disease can present complex problems in diagnosis and management in women who have not been seen before pregnancy. High blood pressure is diagnosed as (1) high blood pressure early in pregnancy, (2) high blood pressure before 20 weeks (unless gestational trophoblastic disease is present), or (3) high blood pressure occurring long after delivery. . Other factors that contribute to the diagnosis of the disease are congestion and high blood pressure, which interfere with earlier pregnancies more than the first. There is often a family history of severe hypertension.

Table 6 From Serum Lactate Dehydrogenase (ldh) Level In Mild And Severe Preeclampsia As A Prognostic Marker

In the case of preeclampsia and eclampsia, functional disorders of many organs and systems are found, probably due to vasospasm and ischemia.

Any convincing theory of the pathophysiology of preeclampsia must take into account the fact that pregnancy-induced hypertension is more difficult to develop in a woman who (1) is first exposed to chorionic villi; (2) they have an excessive amount of chorionic villi, as in twins or a hydatidiform mole; (3) have vascular disease; or (4) has a genetic predisposition to severe disease during pregnancy.

Vasospasm is the basis of the pathophysiology of preeclampsia-eclampsia. This hypothesis is based on direct observation of small blood vessels in the nail bed, eye fundus and bulbar conjunctiva, and on the histological changes observed in various affected organs. Clogged arteries cause resistance to blood flow and lead to the development of high blood pressure. It is possible that the vasospasm itself can damage the vessels. In addition, angiotensin II causes endothelial cell contraction. These changes can lead to endothelial cell damage and interendothelial cell leakage, in which blood components, including platelets and fibrinogen, accumulate subendothelially. These vascular changes, together with local peripheral nerve hypoxia, apparently lead to the hemorrhage, necrosis, and other organ dysfunction seen in severe preeclampsia.

Although pregnancy-related serious illness in women has many potential consequences, for the sake of simplicity, it is discussed here using specific organ systems. A major cause of fetal distress is decreased uteroplacental perfusion.

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Severe abnormalities of normal heart function are common in preeclampsia or eclampsia. These changes are associated with increased cardiac output due to high blood pressure, as well as endothelial damage and extravasation, particularly in the lungs. Fluid management in women with preeclampsia results in increased left ventricular filling while increasing the already normal cardiac output to greater levels.

Preeclampsia is a sign of eclampsia. The lack of increased blood flow in the middle may be due to increased vasoconstriction due to increased blood vessels.

Hematological disorders develop in some, but not all, women who develop gestational hypertension. Thrombocytopenia can sometimes be so severe that it is life-threatening; May reduce the amount of other blocked plasma materials; And erythrocytes can be so injured that they have a strange appearance and rapidly undergo hemolysis.

Ldh High In Pregnancy

Maternal thrombocytopenia may occur especially in pre-eclampsia. After ingestion, the platelet count gradually rises to normal levels over 3-5 days. Severe thrombocytopenia, in which the platelet count is less than 100,000/μL, indicates severe disease (see Table 23-2). In most cases, it is indicated due to a decrease in the number of fertile platelets. In general, the lower the platelet count, the higher the morbidity and mortality of the pregnant woman and child. The combination of elevated liver enzymes in this picture is very dangerous. The combination of these events is called

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– That is, hemolysis (H), elevated liver enzymes (EL) and low platelet count (LP). Neonatal thrombocytopenia is not due to preeclampsia.

Severe coagulation deficits are common in preeclampsia-eclampsia unless there are other coagulopathic events, such as placental abruption or severe hepatic hemorrhage.

Renal blood pressure and glomerular filtration rate are greatly increased during normal pregnancy. As preeclampsia progresses, kidney function and glomerular filtration decline. Blood uric acid levels are often elevated, especially in women with high blood pressure.

Most women with preeclampsia have a slow or low glomerular filtration rate due to reduced blood plasma, resulting in plasma creatinine levels approximately twice the normal value. It should be less than 0.5 mg/dl. However, in some cases of severe preeclampsia, the kidneys are more affected, and plasma creatinine may rise several times that of non-pregnant women, or up to 2 to 3 mg/dL. After recovery, in the absence of acute renal failure, full renal recovery can be expected.

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Necrosis at the edge of the liver lobe is caused by elevated liver enzymes. These tumors can cause bleeding

Central vascular manifestations of preeclampsia, especially shock eclampsia, have been known for a long time. Visual symptoms are another manifestation of brain involvement.

Two different but related types of stroke are severe bleeding, which is caused by rupture of blood vessels caused by high blood pressure. It can be observed in any woman with high blood pressure, and preeclampsia is not necessary for their development.

Ldh High In Pregnancy

Other injuries, different from preeclampsia but more common with eclampsia, are more common and not fatal. The main brain lesions are edema, hyperemia, focal anemia, thrombosis, and hemorrhage.

Thrombocytopenia And Pregnancy

A retinal tear can cause vision changes, although it is usually unilateral and often results in total vision loss, such as in some women with cortical blindness. Surgical treatment is rarely indicated; The prognosis is good and vision usually returns to normal within a week. Cerebral edema can occur in severe cases, and confusion and disorientation are the main symptoms that resolve. In some cases, severe convulsions can occur.

Various biological and biological articles have been published, mainly based on the rationale for the diagnosis and treatment of pregnancy-induced hypertension.

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